Do what you know best

Don't make a strategy game if you have been into action games all your life. Pick a genre you know well and stick to it.

Follow your instinct

There are too many different opinions and good advices out there. You will be ripped in parts if follow every complain you will encounter by feedback. That does not mean feedback is worthless. Write everything down and sort it by importance (e.g. occurance in your feedback stream). Then go through it and fix real issues. Forget the rest.

Don't get browbeaten

Every day brings a new load of game releases. Some of them are similar to your project and just look so good that you can't compete. Should you give up? NO! Brainstorm and make a list of uncommon USPs (unique selling points - features other titles don't have) and add some of them to your game. Differentiation will save your game from drowning in obscurity.