I'm also learning the ropes but here's how I figured so far.
Blender for modelling mesh, UV mapping, Sculpting
Substance Painter for Texturing, Map baking
Here's my workflow:
(!)At this point we have nothing.
1. Model mesh in detail(either subsurf or multires parts)
2. Sculpt details on multires parts(for organics generally)
(!)At this point we have ...