Do video games often use numerical solutions in their calculations, such as you might generate using software like MATLAB or Mathematica?
Perhaps for making formulas for AI, or for game physics implementations?
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While I of course can't guarantee that no counterexample exists, in general maths software will not help you write videogames. While such packages can solve some incredible mathematical problems, it is not the kind of problems you generally face when writing a game. Remember, maths software does not write code, it doesn't even write expressions, it merely transforms the expressions that you feed to it.
Almost all the maths I use as a programmer, whether writing games or other software, is basic algebra. The true art of programming is to find solutions to open ended and vaguely defined problems, such as "How can I convey all the relevant information to the user in a simple and intuitive manner?", or "How can I make the jumping mechanic feel good?". Good luck feeding those problems to Mathematica.
Your question implies being about physics simulation, and that is typically the most maths-heavy part of a videogame. While a good engine will usually use some clever formulas derived using differential maths in order to be as accurate as possible (see for instance Why is RK4 better than Euler integration?), numerical integration is pretty much the only thing you can do.