For business reasons, I would like to know what constitutes satire in a game.
Also, is there a better place to ask questions like this on the business side of game development?
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I think that it would be better to ask on a different forum, but in answer to your question:
Satire is basically ironic humor (usually sarcastic). Satire in a game can be shown in a couple different ways. You can do it visually, by poking fun at a certain stereotypes of a culture (e.g. Have a american person eating a cheeseburger) or it can be verbally. Verbal satire is easy to make, (just look at south park) and is usually a lot funnier. It involves making fun of anything really, from celebrities to culture. (e.g. South Park)
To complete RageGolem10's answer, you need to add billboard messages. The ones you can see as false commercials, or wall grafitis, like "the cake is a lie". Duke nukem had some with false movie posters, like sister act III. You can criticize real life things by mocking them using one single in game image. This is more indirect than speech, because speech is necessarily encountered, so the user is 100% focused on it when it happens. Maybe at the exception of NPC speaking to each other like half life, or mass effect, which is more indirect.