It's peculiar this issue is not well understood on NVIDIA forums and project forums.
For example, the well known ioquake3 project based on id tech 3 requires to force 'Threaded optimization' off on the NVIDIA settings or there are severe FPS drops.
Do you know what a programmer has to do to acquire compatibility with the feature or at least a workaround to not get issues with it (e.g. turning it off explicitly via the application or other means)?
The main importance is that such projects get issues with it by default since not all users know they have to explicitly turn off the feature.