What aspects should I take into consideration for creating character animation and rendering classes if I want to be able to have detachable limbs? I've developed a detailed body system that can have everything down to the nervous system defined. I'm aiming for something similar to the level of damage detail found in Dwarf Fortress. For example, when a character takes damage to their upper arm, there is a chance of nerve damage that can disable the entire arm. Or they could lose the arm entirely.
I have a system written up for handling the data part of this. Each character has a trunk, which has appendages and internal parts. Each appendage can also have child appendages and internal parts. Child appendages are disabled/removed if a parent appendage is disabled/removed. If any of the disabled/removed appendages or internal parts are required for life, the character will soon die.
What I'm working on now is the drawing/animation portion of this. How do I define animations to know which ones are allowed given the current state of the body (missing arms/legs and so on)? How do I set up the drawing system to not draw missing limbs? Does each limb/appendage have to be its own model (I'd like to draw cut off appendages on the ground)?
The simple system I'm transitioning from (I just wrote it for testing) imports all the key frames of an animation as full models into a VBO (along with vertex counts for where key frames start/stop). It doesn't import or utilize the bones defined in Blender, and it doesn't interpolate between frames.
This is likely a pretty big question, so I'm also looking for resources that can get me where I need to go.
EDIT
I ask about the animation knowing which limbs it's animating because I would like to have it set up to perform an alternate animation if a required limb is missing. After thinking about that, I imagine I would perform that check before activating an animation, and activate the appropriate animation at that time.