If you are looking to create destructible terrain, the way I did this in Unity, is to only set colliders on the edge blocks of your world. So for example, this is what you would like to accomplish:

All those green blocks contain a collider, and the rest of them don't. That saves a ton on computations. If you destroy a block, you can activate the colliders on adjacent blocks pretty easily. Keep in mind that activating/deactivating a collider is costly and should be done sparingly.
So, the Tile resource looks like this:

It is a standard gameobject, but it is also poolable. Also notice that the box collider is set to be disabled by default. We would only activate if it is an edge tile.
If you are statically loading your world, there is no need to pool your tiles. You can just load them all in one shot, calculate their distance from the edge, and apply a collider if required.
If you are loading dynamically, it is best to use a tile pool. Here is an edited example of my refresh loop. It loads tiles based on the current camera view:
public void Refresh(Rect view)
{
//Each Tile in the world uses 1 Unity Unit
//Based on the passed in Rect, we calc the start and end X/Y values of the tiles presently on screen
int startx = view.x < 0 ? (int)(view.x + (-view.x % (1)) - 1) : (int)(view.x - (view.x % (1)));
int starty = view.y < 0 ? (int)(view.y + (-view.y % (1)) - 1) : (int)(view.y - (view.y % (1)));
int endx = startx + (int)(view.width);
int endy = starty - (int)(view.height);
int width = endx - startx;
int height = starty - endy;
//Create a disposable hashset to store the tiles that are currently in view
HashSet<Tile> InCurrentView = new HashSet<Tile>();
//Loop through all the visible tiles
for (int i = startx; i <= endx; i += 1)
{
for (int j = starty; j >= endy; j -= 1)
{
int x = i - startx;
int y = starty - j;
if (j > 0 && j < Height)
{
//Get Tile (I wrap my world, that is why I have this mod here)
Tile tile = Blocks[Helper.mod(i, Width), j];
//Add tile to the current view
InCurrentView.Add(tile);
//Load tile if needed
if (!tile.Blank)
{
if (!LoadedTiles.Contains(tile))
{
if (TilePool.AvailableCount > 0)
{
//Grab a tile from the pool
Pool<PoolableGameObject>.Node node = TilePool.Get();
//Disable the collider if we are not at the edge
if (tile.EdgeDistance != 1)
node.Item.GO.GetComponent<BoxCollider2D>().enabled = false;
//Update tile rendering details
node.Item.Set(tile, new Vector2(i, j), DirtSprites[tile.TextureID], tile.Collidable, tile.Blank);
tile.PoolableGameObject = node;
node.Item.Refresh(tile);
//Tile is now loaded, add to LoadedTiles hashset
LoadedTiles.Add(tile);
//if Tile is edge block, then we enable the collider
if (tile.Collidable && tile.EdgeDistance == 1)
node.Item.GO.GetComponent<BoxCollider2D>().enabled = true;
}
}
}
}
}
}
//Get a list of tiles that are no longer in the view
HashSet<Tile> ToRemove = new HashSet<Tile>();
foreach (Tile tile in LoadedTiles)
{
if (!InCurrentView.Contains(tile))
{
ToRemove.Add(tile);
}
}
//Return these tiles to the Pool
//this would be the simplest form of cleanup -- Ideally you would do this based on the distance of the tile from the viewport
foreach (Tile tile in ToRemove)
{
LoadedTiles.Remove(tile);
tile.PoolableGameObject.Item.GO.GetComponent<BoxCollider2D>().enabled = false;
tile.PoolableGameObject.Item.GO.transform.position = new Vector2(Int32.MinValue, Int32.MinValue);
TilePool.Return(tile.PoolableGameObject);
}
LastView = view;
}
Ideally, I'd write a much more detailed post, as there is quite a bit more going on behind the scenes. However, this may help you out. If there are questions feel free to ask or contact me.