The isometric projection is not so much relevant for the underlying tools you choose, it's just the way (angle, no perspective distortion) you look at things, but that doesn't change the underlying principles of how things behave. That means you don't need to particularly search for isometric tools.
The physics for instance is the same, no matter how you look at it. The math of a car crash does not change, whether you look at it from the left or from the right, it does not depend on the observer. The same is true for a bouncing ball, it does not care if you watch it from the left or from top, it will bounce the same way always.
If you have particular doubts about how to implement such things in terms of isometric projections, please tell us an example and we can go into details :)